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Robert H Silverman Selected Research

Double-Stranded RNA (RNA, Double Stranded)

1/2022H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer.
11/2019Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
1/2019Zika Virus Production Is Resistant to RNase L Antiviral Activity.
1/2016Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
9/2008Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.
7/2006PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.
9/2005Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
1/2003Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways.

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Robert H Silverman Research Topics

Disease

40Infections
01/2021 - 05/2002
28Virus Diseases (Viral Diseases)
01/2021 - 01/2002
24Neoplasms (Cancer)
01/2022 - 01/2002
18Prostatic Neoplasms (Prostate Cancer)
01/2022 - 02/2003
9familial Prostate cancer
01/2011 - 12/2002
7Retroviridae Infections (Infection, Retrovirus)
08/2013 - 10/2008
5Vesicular Stomatitis
09/2013 - 05/2003
3Inflammation (Inflammations)
12/2015 - 09/2013
3Melanoma (Melanoma, Malignant)
10/2014 - 01/2003
3Persistent Infection
01/2013 - 02/2003
3Demyelinating Diseases (Demyelinating Disease)
01/2013 - 10/2009
3Carcinoma (Carcinomatosis)
03/2006 - 01/2002
2Zika Virus Infection
01/2021 - 01/2019
2Coronavirus Infections
01/2021 - 01/2017
2Hepatitis
07/2014 - 06/2012
2Ovarian Neoplasms (Ovarian Cancer)
04/2014 - 01/2002
2Herpes Simplex
01/2009 - 04/2003
2Herpes Genitalis (Genital Herpes)
08/2006 - 07/2005
2West Nile Fever
07/2006 - 03/2006
1Flavivirus Infections
01/2021
1COVID-19
11/2020
1Diarrhea
01/2020
1Dehydration (Water Stress)
01/2020
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2019
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
12/2019
1Porcine Reproductive and Respiratory Syndrome (PRRS)
11/2019
1Severe Acute Respiratory Syndrome
01/2017
1Adenocarcinoma of Lung
01/2017
1Common Cold
01/2017
1Neoplasm Metastasis (Metastasis)
12/2015
1Genomic Instability
04/2014
1Chronic Obstructive Pulmonary Disease (COPD)
09/2013
1Viremia
08/2013
1Colitis
05/2013
1Colitis-Associated Neoplasms
05/2013

Drug/Important Bio-Agent (IBA)

582-5A-dependent ribonuclease (RNase L)IBA
01/2021 - 01/2002
33Antiviral Agents (Antivirals)IBA
11/2020 - 01/2002
24InterferonsIBA
01/2022 - 01/2002
18Proteins (Proteins, Gene)FDA Link
11/2019 - 01/2002
17RNA (Ribonucleic Acid)IBA
11/2019 - 02/2003
11Ligases (Synthetase)IBA
11/2020 - 01/2003
8Double-Stranded RNA (RNA, Double Stranded)IBA
01/2022 - 01/2003
82',5'-oligoadenylate (PAPAPA)IBA
11/2020 - 01/2003
7Ribonucleases (Ribonuclease)IBA
11/2020 - 12/2002
7EnzymesIBA
01/2020 - 01/2003
62',5'-Oligoadenylate Synthetase (2',5' Oligoadenylate Synthetase)IBA
01/2020 - 02/2005
6CytokinesIBA
10/2014 - 01/2002
5DNA (Deoxyribonucleic Acid)IBA
12/2019 - 05/2003
5eIF-2 Kinase (eIF 2 Kinase)IBA
09/2013 - 02/2005
4AndrogensIBA
01/2022 - 02/2010
4EndoribonucleasesIBA
04/2014 - 02/2003
4Interferon-betaIBA
01/2006 - 05/2002
3Viral RNAIBA
01/2020 - 03/2006
3Messenger RNA (mRNA)IBA
11/2019 - 04/2003
3Poly I-CIBA
02/2016 - 02/2014
3Adenosine Triphosphate (ATP)IBA
10/2014 - 06/2007
3Small Interfering RNA (siRNA)IBA
04/2014 - 09/2004
3Interferon Type IIBA
02/2014 - 01/2009
2Retroelements (Retrotransposon)IBA
01/2022 - 04/2014
2Pharmaceutical PreparationsIBA
12/2019 - 10/2005
2Interferon-alpha (Interferon Alfa)IBA
11/2019 - 12/2002
2InflammasomesIBA
04/2015 - 10/2014
2Sunitinib (Sutent)FDA Link
09/2013 - 07/2011
2Biological ProductsIBA
01/2012 - 10/2005
2RNA Helicases (RNA Helicase)IBA
02/2011 - 08/2007
2Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2011 - 01/2009
2Androgen Receptors (Androgen Receptor)IBA
11/2010 - 01/2007
2VaccinesIBA
02/2008 - 01/2003
2LigandsIBA
01/2007 - 12/2004
2Carrier Proteins (Binding Protein)IBA
01/2006 - 09/2005
2Complementary DNA (cDNA)IBA
10/2005 - 01/2002
1Androgen Antagonists (Antiandrogens)IBA
01/2022
1Androgen Receptor AntagonistsIBA
01/2022
1A Kinase Anchor ProteinsIBA
01/2021
1Protein Kinases (Protein Kinase)IBA
11/2020
1Adenosine Monophosphate (AMP)IBA
01/2020
1Azacitidine (5 Azacytidine)FDA Link
12/2019
1Biomarkers (Surrogate Marker)IBA
12/2019
1MethyltransferasesIBA
12/2019
1Pattern Recognition ReceptorsIBA
11/2019
1Uridylate-Specific EndoribonucleasesIBA
01/2017
1NucleotidesIBA
10/2014
1NigericinIBA
10/2014
1Interleukin-18 (Interleukin 18)IBA
10/2014
1Particulate MatterIBA
10/2014
1MetalsIBA
04/2014
1Peptide Initiation Factors (Initiation Factor)IBA
09/2013
1SmokeIBA
09/2013
1Pathogen-Associated Molecular Pattern MoleculesIBA
09/2013
1Immunoglobulin G (IgG)IBA
08/2013
1AzoxymethaneIBA
05/2013
1Bacterial RNAIBA
05/2013
1Dextran SulfateIBA
05/2013
1Neutralizing AntibodiesIBA
01/2012
1Protein Isoforms (Isoforms)IBA
12/2011
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2011
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
07/2011
1IFIH1 Interferon-Induced HelicaseIBA
02/2011

Therapy/Procedure

5Therapeutics
01/2022 - 02/2003
1Oncolytic Virotherapy
09/2013